2024 MPN Challenge: Reviewer Scorecard

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Deadline to submit this scorecard is April 1, 2024.

Please review the 2024 MPN Challenge RFA and this Scorecard before reviewing the proposal so that you can score the application.

Funding Program

Application Name

Reviewer Type

Please use a score of 1 to 9 (high to low) to rate the following characteristics of this proposal. Fractions (e.g., 1.7) are not admissible scores. (Note: see table below for description of each score level).

REVIEW

Relevance to Foundation mission and primary objective of this award mechanism: (To stimulate innovative and clinically relevant research with potential for near-term patient impact. To expand upon current understanding of the basic biology of the MPNs, develop a deeper understanding of what is driving the development and progression of disease and address critical gaps slowing the development of new therapeutic approaches.)

Research Plan and Feasibility of project (reasonable expectation that

project will yield the planned results in a 2-year timeframe)

Innovation (initial exploration of new ideas with potential to open new avenues of investigation)

Potential for Near-Term Patient Impact: (Accomplishment of the specific aims to advance our knowledge of MPN causes, prevention or cure. It is clear from the narrative that the research has the potential to impact patients.)

Research environment and support

OVERALL SCORE: Reflecting overall view of the proposal and not necessarily the average of individual scores above. (Proposals with an overall score of 4-9 would generally not be considered for funding.)

COMMENTS

Please capture the key strengths and weaknesses of the proposal (required)

Strengths

Weakness

General Comments

PATIENT REVIEW

LAY SUMMARY: Is the lay summary of the research application written clearly? (see Readability Consensus)

Lay Summary Comments:

PATIENT IMPACT: Will the accomplishment of the specific aims advance our knowledge of MPN causes, prevention or cure? Is it clear from the narrative that their research has the potential to impact patients?

Patient Impact Comments:

Please reference the below chart for the following question:

OVERALL SCORE: Overall assessment of the value of the grant proposal. What is the likelihood of the project having a powerful influence on MPN research and patients? See image below for Overall Impact Score guidance.

Reflecting overall view of the proposal and not necessarily the average of individual scores above. (Proposals with an overall score of 4-9 would generally not be considered for funding.)

MPNRF FOCUS AREA: Does this proposal fit with one of the focus areas defined by MPNRF? In addition to these topics, MPNRF will consider any request that advances our knowledge of the development and treatment of MPNs. The overall score should not be negatively impacted if the proposal does not fall into one of these focus areas.

Harnessing the immune system to improve long term outcomes for patients with an MPN – research directed at developing novel immunotherapeutic strategies by exploring multiple avenues relating to the immune system and MPNs, e.g., immune dysregulation and/or silencing.   
Strategies directed at earlier intervention and/or prevention of MPNs – While open to all approaches, this is intended particularly towards new, non-conventional, research approaches that involve combining traditional and complementary therapies.
Quality of Life (QoL) – Research projects that lead to reduction of symptom burden including anemia/fatigue; augmenting existing therapies with alternative treatments such as nutrition, coping strategies for anxiety, and depression using meditation, movement, sound, activities, etc.
Spatial analysis of the bone marrow microenvironment towards personalized therapeutics development – Use of spatial analysis of individual patient bone marrow provides the opportunity for more personalized therapeutic strategies and development of new drug targets. We are seeking proposals that will help adapt this currently costly, low throughput approach for clinical care of MPN patients.
Research using relevant human disease models – we are seeking more research that uses primary human MPN samples and/or human disease derived models to enhance decision-making for future therapeutic targets and treatment strategies.
Biology of progression of chronic phase MPN to AML – research leading to a greater understanding and exploiting the mechanisms that lead to transformation to acute myeloid leukemia (AML).
Optimize patient therapy decisions – with many new treatment options available or under investigation for MPN patients, we are seeking proposals that utilize patient genomic and/or other clinical characteristics to optimize success with their choice of treatment.

Does this proposal fit with one of the focus areas defined by MPNRF?

YesNo

Comments:

PATIENT COMMENTS

PATIENT PERSPECTIVE: What recommendations or suggestions for improvement would you like to give to the researchers to optimize the research from the perspective of patients?

SUMMARY: list any major strengths and weaknesses (optional)

Would you like to see this project funded? Please review the number you provided for the Overall Score? (Proposals with an overall score of 4-9 would generally not be considered for funding.)

YesNo

ADDITIONAL COMMENTS:

By checking this box, you confirm that you have no conflict of interest with the application, researchers and/or the institution.

There is no Conflict of Interest with this application.

Reviewer Email

Email is required so that you can receive a copy of what you submitted.

Review Salesforce ID

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